How difficult is it for new entrants to come in and manufacture plasmids?

It's amusing how many conversations we have with people who grow a bit of plasmid in a lab and don't understand the complexities involved. They often ask, "Why can't you just make it?" LB broth is inexpensive, so they suggest making a bigger batch. However, it becomes cumbersome when you start using 30-liter fermenters and above. You need a lot of expertise to lyse the cells and maintain DNA integrity, especially with AAV, which is prevalent in the market. The transgene, the main component sourced, is a large plasmid and doesn't behave well at large scales.